Akuamma (Picralima nitida) is a tree native to West Africa whose dried seeds have been traditionally used in medicine to relive pain, reduce fever and treat malaria. The seeds contain indole alkaloids, primarily akuammine, which interact with opioid receptors in the body. Akuamma is native to several central African countries.

Akuammine and pseudo-akuammigine are indole alkaloids found in the seeds of the akuamma tree (Picralima nitida). Both alkaloids are weak agonists of the mu opioid receptor; however, they produce minimal effects in animal models of antinociception.

Traditional Uses

Traditional and Modern Uses

Akuamma seeds have been used for centuries in African traditional medicine to treat a variety of ailments. Modern wellness uses, available in the form of whole seeds, powder, capsules, and tinctures, include: 

Other Uses: Traditionally used for fevers, malaria, digestive support, and as an anti-diarrheal and antimicrobial agent. 

Pain Management: Used for natural pain relief, including back pain, migraines, and arthritis.

Sleep Aid: Its mild sedative properties can help with relaxation and sleep issues.

Stress and Mood: May offer relaxation, stress relief, and mood enhancement.

Anti-inflammatory: Has potential anti-inflammatory properties.